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New England Journal of Medicine , 385(6), 503-515
The medication was effective but required reconstitution before each injection, which patients found inconvenient
SAMe is the universal methyl donor and is used for DNA methylation and to make phospholipid membranes, choline, sphingomyelin, acetylcholine, and other neurotransmitters
Recombinant Klotho protein enhances cholesterol efflux of THP-1 macrophage-derived foam cells via suppressing Wnt/beta-catenin signaling pathway
Unknown long-term profile: Human long-term safety data are limited, so caution and monitoring are advised
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